Discovery of the endocannabinoid system

How can a substance that is produced by the body itself be harmful, addictive and classified as a drug?

It all started with the discovery of THC and anandamide.

Anandamide (from Sanskrit, ananda = bliss / joy / pure happiness) is an ethanol amine derivative of arachidonic acid, a four-fold unsaturated fatty acid that is particularly common in the central nervous system. Anandamine is produced by the body itself (if linoleic acid is present) and is considered an endogenous substance and the counterpart to tetrahydrocannabinol (THC).

Professor Raphael Mechoulam (forefather of cannabis research) and Professor Yechiel Gaoni discovered the THC in the cannabis sativa in 1964. Then came the final breakthrough in 1992. The endocannabinoid system (ECS, endogenous cannabinoid system) was established through the discovery of anandamide and thus the presence of the endocannabinoid system and its receptors CB1 and CB2.

Not only does the human body have the endocannabinoid system (ECS) but also mammals, birds, fish, reptiles and even sea urchins.

Cocoa - Theobroma cacao

Cacao influences the endocannabinoid system by deactivating the FAAH enzyme, which is responsible for the image of the anandamide. Anandamide is a natural version of THC that our body can produce itself. Consuming natural chocolate increases the levels of anandamides in the brain because the function of the FAAH enzyme is decreased. The effect is similar to smoking cannabis - you feel relaxed and happy - but not the same as after consuming THC. Researchers from the Neuroscience Institute in San Diego have confirmed that chocolate contains 3 compounds that act like cannabinoids behavior
Terms for hemp names.

Useful information!!!


Hemp is a genus of plants within the hemp family. The hemp plant is one of the oldest useful and ornamental plants on earth.


Cannabis is the Latin word for hemp. The term cannabis is often used extensively for hemp plants and THC-containing products of the plant and, in my opinion, is incorrectly referred to as a drug.

Marijuana, weed

Marijuana is the name given to the dried flowers of the female plant. The resin, which contains high concentrations of THC, CBD and other cannabinoids, sits on the glandular hairs of this plant. Furthermore, the term marijuana is a Mexican slang / slang for hemp.

Haschisch, Dope, Shit

Hashish is an extract of resin and plant parts of the female hemp plant, which is pressed into plates and blocks. In scientific parlance, however, the term (dope / shit) actually stands for dried parts of plants. Shit is also known as (bad) hashish.

Industrial hemp

Industrial hemp or industrial hemp includes all varieties of hemp, but above all the cannabis sativa variety (cannabis genus), is grown for commercial use - apart from its use.